Plant Natural Products as Potential Modulators of the Transcription Factor NF- B

Nuclear factorB (NFB) is an inducible transcription factor which plays important role in the regulation of the immune, inflammatory and carcinogenic responses. Partial NFB activation is necessary for normal cell survival and immunity; however the deregulated NFB expression is associated with cancer development, metastasis, and in several inflammatory disorders with a resistant phenotype and poor prognosis. Therefore, NFB has become an interesting target for drug discovery and several natural and synthetic products have been screened for their ability to inhibit NFB pathway. This review surveys the plant natural products with significant NFB inhibitory activity focusing on their potential mechanism of action and their implications for cancer therapy. _____________________________________________________________________________________________________________